David Holmes served as a Senator from Mississippi in the United States Congress from 1797 to 1825. A member of the Republican Party, David Holmes contributed to the legislative process during 8 terms in office.

David Holmes’s service in Congress occurred during a significant period in American history. As a member of the Senate, David Holmes participated in the democratic process and represented the interests of constituents.

David Holmes (March 10, 1769 – August 20, 1832) was an American politician in Virginia and Mississippi. He served five terms as a U.S. congressman from Virginia’s 2nd congressional district and later was important in Mississippi’s development as a state. The federal government appointed him as the fourth and last governor of the Mississippi Territory. In 1817, he was unanimously elected as the first governor of the state of Mississippi. He served a term as U.S. senator from Mississippi, appointed to fill a vacancy until elected by the legislature. Elected again as governor, he was forced to resign early due to ill health. He returned to Virginia in his last years.