James Donald Cameron (born May 14, 1833) was a Republican senator from Pennsylvania who served in the United States Senate from October 15, 1877, to March 3, 1897. Over the course of his two-decade tenure, he completed four terms in office, representing Pennsylvania at the federal level during a period of significant political and economic change in the post–Civil War and Gilded Age eras.

Cameron’s service in the Senate was defined by his long-standing role as a Republican lawmaker from Pennsylvania, though specific committee assignments or leadership positions are not detailed in the available record. As a historical member of Congress, his career is noted primarily for its duration and continuity, reflecting sustained support from his state and party. He left office in 1897, concluding twenty years as a United States senator.