James O’Brien (born March 13, 1841) was an American politician who represented New York in the United States House of Representatives. Serving as an Independent, he held office as the representative for New York’s 10th Congressional District. His tenure in Congress began on March 18, 1879, and concluded on March 3, 1881, encompassing a single term in the U.S. House.

During his time in office, O’Brien served as a Representative from New York, identified in congressional records by the bioguide ID O000011. Although details of his committee assignments, legislative initiatives, and professional activities outside Congress are not provided in the available metadata, his service from 1879 to 1881 places him among the historical members of Congress from New York. After leaving office, he is recorded as a former member, with no further official roles or contact information listed in the provided record.