José Lorenzo Pesquera (born August 10, 1882) was a nonpartisan Puerto Rican politician who served as a Resident Commissioner in the United States House of Representatives. Representing Puerto Rico at-large, he held office as a Representative from December 7, 1931, to March 3, 1933. His service placed him among the historical members of Congress who spoke for Puerto Rico in the federal legislature during the early twentieth century.

Pesquera’s tenure in Congress lasted for one term, during which he served as a nonvoting delegate for Puerto Rico rather than as a member representing a U.S. state. Although specific committee assignments, legislative initiatives, and additional offices are not recorded in the available metadata, his role as an at-large Representative underscored his responsibility to represent the interests of the entire territory. He left office on March 3, 1933, concluding his formal congressional service as a former Representative from Puerto Rico.